4-N,N-二(2-氯乙基)氨基苯氧基乙酸合成路线 （共 5 条）
反应条件
hydrogenchloride 1 h; Heating;
参考文献
Schatzschneider, Ulrich; Barton, Jacqueline K.
Journal of the American Chemical Society, 2004 , vol. 126, # 28 p. 8630 - 8631
反应条件
1: 22.5 percent / aq. acetic acid / 0 °C 2: 63.3 percent / POCl3 / benzene / 1 h / 100 - 110 °C 3: 59.8 percent / aq. HCl / 1 h / Heating View Scheme
参考文献
Davis et al.
Journal of the Chemical Society, 1955 , p. 890,894
反应条件
1: 63.3 percent / POCl3 / benzene / 1 h / 100 - 110 °C 2: 59.8 percent / aq. HCl / 1 h / Heating View Scheme
参考文献
Davis et al.
Journal of the Chemical Society, 1955 , p. 890,894
反应条件
1.1: NaH / dimethylformamide / 0.5 h / 0 °C 1.2: 27.5 percent / dimethylformamide / 0 - 20 °C 2.1: 22.5 percent / aq. acetic acid / 0 °C 3.1: 63.3 percent / POCl3 / benzene / 1 h / 100 - 110 °C 4.1: 59.8 percent / aq. HCl / 1 h / Heating View Scheme
参考文献
Schatzschneider, Ulrich; Barton, Jacqueline K.
Journal of the American Chemical Society, 2004 , vol. 126, # 28 p. 8630 - 8631
反应条件
dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine in dichloromethane
24 h; Ambient temperature;
参考文献
Pairas; Camoutsis Ch.; Catsoulacos
European Journal of Medicinal Chemistry, 1985 , vol. 20, # 3 p. 287 - 288
