4-氯-6-氟吡啶并[3,4-D]嘧啶合成路线 (共 4 条)
反应条件
thionyl chloride in DMF (N,N-dimethyl-formamide) 7 h; Heating / reflux;
参考文献
Pfizer Products Inc.
Patent: EP1249451 A2, 2002 ;
Location in patent: Page 17 ;
反应条件
thionyl chloride in dichloromethane; tert-butyl methyl ether; 1,2-dichloro-ethane
参考文献
US6313292 B1, ;
US 6313292 B1
反应条件
in isopropyl alcohol 0.75 h; Heating;
参考文献
Rewcastle, Gordon W.; Murray, Donna K.; Elliott, William L.; Fry, David W.; Howard, Curtis T.; Nelson, James M.; Roberts, Billy J.; Vincent, Patrick W.; Hollis Showalter; Thomas Winters; Denny, William A.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 5 p. 742 - 751
参考文献
Warner-Lambert Company
Patent: US6313292 B1, 2001 ;
US 6313292 B1