4,6-二氯-吡啶并[3,2-d]嘧啶合成路线 （共 7 条）
反应条件
thionyl chloride in DMF (N,N-dimethyl-formamide) 1.5 h; Heating / reflux;
参考文献
WO2005/58913 A1, ;
Page/Page column 36 ;
反应条件
1: With N-ethyl-N,N-diisopropylamine; trichlorophosphate in toluene Reflux; 2: With sodium hydrogencarbonate in dichloromethane Cooling;
参考文献
WO2010/101949 A1, ;
Page/Page column 110; 111 ;
WO 2010/101949 A1
反应条件
1: 73 percent / 90percent H2SO4 / 3.5 h / 70 °C 2: H2 / 5percent Pd/C / ethyl acetate / 3102.9 Torr 3: 18 h / Heating 4: 73 percent / POCl3 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 9 p. 1823 - 1835
反应条件
1: H2 / 5percent Pd/C / ethyl acetate / 3102.9 Torr 2: 18 h / Heating 3: 73 percent / POCl3 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 9 p. 1823 - 1835
反应条件
1: 18 h / Heating 2: 73 percent / POCl3 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 9 p. 1823 - 1835
反应条件
1.1: 1-methyl-pyrrolidin-2-one / 0.67 h / 20 - 180 °C 2.1: ammonium hydroxide; water / 0.33 h / 20 °C 2.2: 3 h / 20 °C 3.1: 3 h / Reflux 4.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 1 h / 20 - 110 °C View Scheme
参考文献
US2012/238587 A1, ;
US 20120238587 A1
反应条件
in dichloromethane
T=0 - 20°C; 2 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/39140 A1, 2009 ;
Location in patent: Page/Page column 49 ;
WO 2009/039140 A1
