(S)-(+)-2,3,7,7A-四氢-7A-甲基-1H-茚-1,5(6H)-二酮合成路线 （共 26 条）
反应条件
acetic acid in water T=20°C; Robinson Annulation; 48 h; Time; enantioselective reaction;
参考文献
Tetrahedron Letters, , vol. 54, # 24 p. 3101 - 3104
反应条件
molecular sieve; toluene-4-sulfonic acid in toluene 5 h; Heating;
参考文献
Tetrahedron, , vol. 54, # 14 p. 3439 - 3456
反应条件
magnesium chloride in dimethyl sulfoxide T=130°C; Decarboxylation; deketalization; 4 h;
参考文献
European Journal of Organic Chemistry, , # 18 p. 3165 - 3169
反应条件
toluene-4-sulfonic acid; L-proline 1.) CHCl3, rt, 54 h, 2.) benzene, reflux, 2 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 61, # 10 p. 3520 - 3530
反应条件
toluene-4-sulfonic acid in toluene 5 h; Heating; Title compound not separated from byproducts.;
参考文献
Organic and Biomolecular Chemistry, , vol. 5, # 19 p. 3190 - 3200
反应条件
(i) L-proline, DMF, (ii) TsOH*H2O, benzene; Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 40, p. 675 - 681
反应条件
1: yeast cells of Torulaspora delbrueckii IFO10921; glucose / aq. phosphate buffer / 3 h / 30 °C / pH 6.5 / Enzymatic reaction 2: Jones reagent View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 345, # 6-7 p. 766 - 774
反应条件
1: 100 percent / triethylamine / acetonitrile / 20 °C 2: (S)-5,6-dimethyl-2-(pyrrolidin-2-yl)-1H-benzimidazole; TFA / tetrahydrofuran / 48 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 1 p. 167 - 177
反应条件
1: 2-methyl-1,3-cyclo-pentanedione With L-proline in dimethyl sulfoxide T=15 - 25°C; 6 h; 2: methyl vinyl ketone in dimethyl sulfoxide T=15 - 25°C; asymmetric Robinson annulation; 145 h; 3: With pyridinium p-toluenesulfonate in benzene 2 h; Heating;
参考文献
Tetrahedron Letters, , vol. 42, # 29 p. 4887 - 4890
