(S)-(+)-2,3,7,7A-四氢-7A-甲基-1H-茚-1,5(6H)-二酮合成路线 （共 26 条）
反应条件
L-proline in chloroform T=20°C; Hajos-Parrish reaction; 316 h; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron, , vol. 65, # 25 p. 4841 - 4845
反应条件
pyridine; chromium(VI) oxide
参考文献
Helvetica Chimica Acta, , vol. 41, p. 1428,1430
反应条件
1.1: 80 percent / p-toluenesulfonic acid / toluene / 12 h / Heating 2.1: ZnCl2; hydroquinone / tetrahydrofuran / 2 h / 0 °C 2.2: 70 percent / acetic acid; H2O 3.1: 70 percent / LiCl; DBU / tetrahydrofuran / 1 h / -78 °C 4.1: 85 percent / TMSOTf / CH2Cl2 / 20 h / -78 °C 5.1: 65 percent / MeONa / benzene / 12 h / Heating 6.1: 90 percent / MgCl2 hexahydrate / dimethylsulfoxide / 4 h / 130 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 18 p. 3165 - 3169
反应条件
1: 85 percent / TMSOTf / CH2Cl2 / 20 h / -78 °C 2: 65 percent / MeONa / benzene / 12 h / Heating 3: 90 percent / MgCl2 hexahydrate / dimethylsulfoxide / 4 h / 130 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 18 p. 3165 - 3169
反应条件
1.1: ZnCl2; hydroquinone / tetrahydrofuran / 2 h / 0 °C 1.2: 70 percent / acetic acid; H2O 2.1: 70 percent / LiCl; DBU / tetrahydrofuran / 1 h / -78 °C 3.1: 85 percent / TMSOTf / CH2Cl2 / 20 h / -78 °C 4.1: 65 percent / MeONa / benzene / 12 h / Heating 5.1: 90 percent / MgCl2 hexahydrate / dimethylsulfoxide / 4 h / 130 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 18 p. 3165 - 3169
反应条件
1: 65 percent / MeONa / benzene / 12 h / Heating 2: 90 percent / MgCl2 hexahydrate / dimethylsulfoxide / 4 h / 130 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 18 p. 3165 - 3169
反应条件
1: 70 percent / LiCl; DBU / tetrahydrofuran / 1 h / -78 °C 2: 85 percent / TMSOTf / CH2Cl2 / 20 h / -78 °C 3: 65 percent / MeONa / benzene / 12 h / Heating 4: 90 percent / MgCl2 hexahydrate / dimethylsulfoxide / 4 h / 130 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 18 p. 3165 - 3169
反应条件
trifluorormethanesulfonic acid; (S)-N1,N1-diethyl-3,3-dimethylbutane-1,2-diamine; meta-nitrobenzoic acid in neat (no solvent) T=60°C; Robinson Annulation; 144 h; Overall yield = 79 percent; enantioselective reaction;
参考文献
Synthesis (Germany), , vol. 45, # 14 art. no. SS-2013-E0218-FA, p. 1939 - 1945
反应条件
toluene-4-sulfonic acid in toluene 5 h; Heating; Title compound not separated from byproducts.;
参考文献
Organic and Biomolecular Chemistry, , vol. 5, # 19 p. 3190 - 3200
反应条件
2: aq. NaOH 3: CrO3, H2SO4 / acetone View Scheme
参考文献
Tetrahedron, , vol. 24, p. 2039 - 2046
