6-氯-3,4-二氢-2(1H)-萘酮合成路线 （共 13 条）
反应条件
aluminium trichloride in dichloromethane Cyclization;
参考文献
Nevy, John B.; Hawkinson, David C.; Blotny, Grzegorz; Yao, Xudong; Pollack, Ralph M.
Journal of the American Chemical Society, 1997 , vol. 119, # 52 p. 12722 - 12726
反应条件
titanium tetrachloride in dichloromethane T=-78 - 20°C; 5 h;
参考文献
Hon, Yung-Son; Devulapally, Rammohan
Tetrahedron Letters, 2009 , vol. 50, # 23 p. 2831 - 2834
反应条件
titanium tetrachloride in dichloromethane T=0 - 20°C; Friedel Crafts reaction; 5 h;
参考文献
Tetrahedron Letters, , vol. 50, # 41 p. 5713 - 5715
反应条件
1: thionyl chloride / 1,2-dichloro-ethane / Heating 2: AlCl3 / CH2Cl2 / -5 - 5 °C View Scheme
参考文献
Synthetic Communications, , vol. 33, # 13 p. 2215 - 2227
反应条件
magnesium bromide in diethyl ether; toluene 1) 1 h, r.t., 2) 3 h, reflux; Yield given;
参考文献
Chemische Berichte, , vol. 116, # 9 p. 3086 - 3096
反应条件
1: NaBH4 / ethanol / 2 h / 40 °C 2: 93 percent / TosOH / toluene / 2 h / Heating 3: m-chloroperbenzoic acid / CH2Cl2 / 5 h / Ambient temperature 4: MgBr2 / toluene; diethyl ether / 1) 1 h, r.t., 2) 3 h, reflux View Scheme
参考文献
Chemische Berichte, , vol. 116, # 9 p. 3086 - 3096
反应条件
1: 93 percent / TosOH / toluene / 2 h / Heating 2: m-chloroperbenzoic acid / CH2Cl2 / 5 h / Ambient temperature 3: MgBr2 / toluene; diethyl ether / 1) 1 h, r.t., 2) 3 h, reflux View Scheme
参考文献
Chemische Berichte, , vol. 116, # 9 p. 3086 - 3096
反应条件
1: m-chloroperbenzoic acid / CH2Cl2 / 5 h / Ambient temperature 2: MgBr2 / toluene; diethyl ether / 1) 1 h, r.t., 2) 3 h, reflux View Scheme
参考文献
Chemische Berichte, , vol. 116, # 9 p. 3086 - 3096
反应条件
1: 72 percent / (NH4)2CO3 / ethanol; H2O / 6 h / 60 °C 2: 57 percent / Ba(OH)2, water / 3 h / 160 °C 3: 57 percent / Ba(OH)2, water / 3 h / 160 °C View Scheme
参考文献
Grouiller; Nioche; Barailler; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 139 - 146
反应条件
1: 72 percent / (NH4)2CO3 / ethanol; H2O / 6 h / 60 °C
2: 57 percent / Ba(OH)2, water / 3 h / 160 °C
View Scheme
参考文献
Grouiller; Nioche; Barailler; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 139 - 146
