反应条件
Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '131208', constants.ctx, '0')">2-hydroxy-1,3-isoindolinedione</a> <b>With</b> <a href="#" onclick="return RXDsubstances(event, this, '4122952', constants.ctx, '0')">sodium hydride</a> <b>in</b> <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a> <br />Metallation; <br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '605833', constants.ctx, '0')">1-[(E)-3-bromo-1-propenyl]benzene</a> <b>With</b> <a href="#" onclick="return RXDsubstances(event, this, '8127930', constants.ctx, '0')">sodium iodide</a> <b>in</b> <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a> <br />T=70°C; Alkylation; 22 h; <br />
参考文献
High; Prior; Bell; Rangachari Journal of Pharmacology and Experimental Therapeutics, 1999 , vol. 288, # 2 p. 490 - 501