1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 6 h / 50 - 60 °C 2.1: tetrahydrofuran / -15 - 25 °C / Inert atmosphere 2.2: 0 - 5 °C 3.1: sodium hydride / toluene / 1 h / 20 °C / Inert atmosphere 3.2: 4 h / 45 - 50 °C 3.3: 0 - 5 °C / pH 1 4.1: lithium chloride / dimethyl sulfoxide / 15 h / 150 - 160 °C 5.1: sodium hydroxide / ethylene glycol / 4 h / 170 - 180 °C 5.2: pH 1 6.1: di-isopropyl ether / 6 h / 20 - 75 °C 7.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 8.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 9.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 10.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 10.2: 0.5 h / 0 - 5 °C View Scheme

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 3 h / 25 °C 2.1: sodium hydride / toluene / 1 h / 20 °C / Inert atmosphere 2.2: 4 h / 45 - 50 °C 2.3: 0 - 5 °C / pH 1 3.1: lithium chloride / dimethyl sulfoxide / 15 h / 150 - 160 °C 4.1: sodium hydroxide / ethylene glycol / 4 h / 170 - 180 °C 4.2: pH 1 5.1: di-isopropyl ether / 6 h / 20 - 75 °C 6.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 7.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 8.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 9.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 9.2: 0.5 h / 0 - 5 °C View Scheme

1.1: sodium hydride / toluene / 1 h / 20 °C / Inert atmosphere 1.2: 4 h / 45 - 50 °C 1.3: 0 - 5 °C / pH 1 2.1: lithium chloride / dimethyl sulfoxide / 15 h / 150 - 160 °C 3.1: sodium hydroxide / ethylene glycol / 4 h / 170 - 180 °C 3.2: pH 1 4.1: di-isopropyl ether / 6 h / 20 - 75 °C 5.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 6.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 7.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 8.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 8.2: 0.5 h / 0 - 5 °C View Scheme

1.1: diisobutylaluminium hydride / toluene / -15 - 20 °C / Inert atmosphere 1.2: Cooling with ice 2.1: carbon tetrabromide / 10 h / 60 °C 3.1: triethylamine; lithium hexamethyldisilazane / toluene / 2.83 h / -60 °C / Inert atmosphere 3.2: 0.17 h 3.3: Cooling with ice 4.1: hydrogen / 5 palladium on charcoal / methanol / 18 h / 20 °C / 3000.3 Torr 5.1: thionyl chloride / toluene / 4 h / 90 °C 6.1: triethylamine / dichloromethane / 0.83 h / 20 °C / Cooling with ice 7.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 1 h / Inert atmosphere; Reflux 7.2: 0.5 h / 20 °C / Cooling with ice View Scheme

1.1: tetrahydrofuran / -15 - 25 °C / Inert atmosphere 1.2: 0 - 5 °C 2.1: potassium carbonate / dimethyl sulfoxide / 0.25 h / 25 °C 2.2: 1 h / 25 °C 3.1: tri-n-butyl-tin hydride / 2,2'-azo-bisisobutyronitrile / toluene / 10 h / Reflux 3.2: 20 °C 4.1: sodium hydroxide / ethylene glycol / 4 h / 170 - 180 °C 4.2: pH 1 5.1: di-isopropyl ether / 6 h / 20 - 75 °C 6.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 7.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 8.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 9.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 9.2: 0.5 h / 0 - 5 °C View Scheme

1.1: potassium carbonate / dimethyl sulfoxide / 0.25 h / 25 °C 1.2: 1 h / 25 °C 2.1: tri-n-butyl-tin hydride / 2,2'-azo-bisisobutyronitrile / toluene / 10 h / Reflux 2.2: 20 °C 3.1: sodium hydroxide / ethylene glycol / 4 h / 170 - 180 °C 3.2: pH 1 4.1: di-isopropyl ether / 6 h / 20 - 75 °C 5.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 6.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 7.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 8.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 8.2: 0.5 h / 0 - 5 °C View Scheme

1.1: tri-n-butyl-tin hydride / 2,2'-azo-bisisobutyronitrile / toluene / 10 h / Reflux 1.2: 20 °C 2.1: sodium hydroxide / ethylene glycol / 4 h / 170 - 180 °C 2.2: pH 1 3.1: di-isopropyl ether / 6 h / 20 - 75 °C 4.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 5.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 6.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 7.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 7.2: 0.5 h / 0 - 5 °C View Scheme

1.1: sodium hydroxide / ethylene glycol / 4 h / 170 - 180 °C 1.2: pH 1 2.1: di-isopropyl ether / 6 h / 20 - 75 °C 3.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 4.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 5.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 6.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 6.2: 0.5 h / 0 - 5 °C View Scheme

1.1: di-isopropyl ether / 6 h / 20 - 75 °C 2.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 3.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 4.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 5.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 5.2: 0.5 h / 0 - 5 °C View Scheme

1.1: sodium hydroxide / ethylene glycol / 4 h / 170 - 180 °C 1.2: pH 1 2.1: di-isopropyl ether / 6 h / 20 - 75 °C 3.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 4.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 5.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 6.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 6.2: 0.5 h / 0 - 5 °C View Scheme