(2E)-3-(4-氨基苯基)-2-丙烯酸合成路线 （共 12 条）
参考文献
Ogita, Haruhisa; Isobe, Yoshiaki; Takaku, Haruo; Sekine, Rena; Goto, Yuso; Misawa, Satoru; Hayashi, Hideya
Chemical and pharmaceutical bulletin, 2003 , vol. 51, # 2 p. 117 - 121
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water T=20°C; 16 h;
参考文献
Pardin, Christophe; Pelletier, Joelle N.; Lubell, William D.; Keillor, Jeffrey W.
Journal of Organic Chemistry, 2008 , vol. 73, # 15 p. 5766 - 5775
反应条件
in tetrahydrofuran T=20°C; 24 h;
参考文献
Miyawaki, Atsuhisa; Miyauchi, Masahiko; Takashima, Yoshinori; Yamaguchi, Hiroyasu; Harada, Akira
Chemical Communications, 2008 , vol. 8, # 4 p. 456 - 458
反应条件
1: 94 percent / H2, AcOH/MeOH / 10percent Pd/C 2: 1.) 1 M NaNO2, 2 M HCl, 2.) 1 M NaN3 / 1.) 0 deg C, 15 min, 2.) 90 min View Scheme
参考文献
Carnazzi; Aumelas; Barberis; Guillon; Seyer
Journal of Medicinal Chemistry, 1994 , vol. 37, # 12 p. 1841 - 1849
反应条件
1: H2 / 10percent Pd/C / 2-methoxy-ethanol / 3 h / 20 °C / 3040.2 Torr 2: SOCl2 / 20 °C View Scheme
参考文献
The Green Cross Corporation
Patent: US5635527 A1, 1997 ;
反应条件
Yield given. Multistep reaction;
参考文献
Ashimori; Ono; Inoue; Morimoto; Eda; Uchida; Ohtaki; Fujino; Kido; Ogura; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 1 p. 91 - 99
反应条件
methanol; hydrogen; acetic acid; palladium on activated charcoal
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 12 p. 1841 - 1849
反应条件
sodium hydroxide T=20°C; im Rohr;
参考文献
Pfeiffer; Haefelin
Chemische Berichte, 1922 , vol. 55, p. 1771
参考文献
Vorlaender
Chemische Berichte, 1938 , vol. 71, p. 501,504, 517
反应条件
hydrogenchloride in 1,4-dioxane; methanol
参考文献
MethylGene, Inc.
Patent: US6897220 B2, 2005 ;
US 6897220 B2
