2-溴-1-(2-吡啶基)-1-乙酮氢溴酸合成路线 （共 7 条）
反应条件
pyridinium tribromide; hydrogen bromide; acetic acid T=20°C; 23 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/4117 A1, 2008 ;
Location in patent: Page/Page column 85 ;
反应条件
hydrogen bromide; bromine; acetic acid in water T=20°C;
参考文献
Pharmacia Italia S.p.A.
Patent: US2007/142414 A1, 2007 ;
Location in patent: Page/Page column 18 ;
US 20070142414 A1
反应条件
bromine in acetic acid; benzene T=60°C;
参考文献
Ruano, J. L. Garcia; Pedregal, C.; Rodriguez, J. H.
Tetrahedron, 1987 , vol. 43, # 19 p. 4407 - 4416
反应条件
1: 97.5 percent / methanol / Ambient temperature 2: 93 percent / sodium metaperiodate / further reagent 3: m-cloroperbenzoic acid View Scheme
参考文献
Ruano, J. L. Garcia; Pedregal, C.; Rodriguez, J. H.
Tetrahedron, 1987 , vol. 43, # 19 p. 4407 - 4416
反应条件
1: With ammonium acetate in ethanol T=20°C; 2: With hydrogenchloride; methanol in 1,4-dioxane 0.5 h;
参考文献
US2007/142414 A1, ;
Page/Page column 19 ;
US 20070142414 A1
反应条件
1: With water T=23°C; 0.5 h; Inert atmosphere; 2: With ammonium hydroxide Inert atmosphereAlkaline conditions;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 21 p. 6385 - 6397
反应条件
1: 97.5 percent / methanol / Ambient temperature
2: 93 percent / sodium metaperiodate / further reagent
View Scheme
参考文献
Ruano, J. L. Garcia; Pedregal, C.; Rodriguez, J. H.
Tetrahedron, 1987 , vol. 43, # 19 p. 4407 - 4416
