4-羟基-7-甲氧基香豆酯合成路线 （共 31 条）
反应条件
1: 1) Na2CO3*10H2O, 2) Na2CO3*10H2O / 1) H2O, RT, 30 min, 2) H2O, RT, 2h 2: 50 percent / dimethylformamide / 0.17 h / Heating 3: 75 percent / NEt3 / PdCl2 / 8 h / Heating 4: 40percent HBr/HOAc / 1 h / Heating View Scheme
参考文献
Laschober; Kappe
Synthesis, 1990 , # 5 p. 387 - 388
参考文献
Jain, Monish; Kwon, Chul-Hoon
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5428 - 5436
反应条件
potassium carbonate in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
Raffa, Guillaume; Belot, Sebastien; Balme, Genevieve; Monteiro, Nuno
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 5 p. 1474 - 1478
反应条件
1: pyridine; piperidine 2: boron fluoride ether adduct / 130 °C 3: aq.-ethanolic hydrochloric acid View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 24, p. 3471,3474
反应条件
hydrogen iodide in acetic anhydride; acetic acid
T=120°C; 3.5 h; Reflux;
参考文献
Andres, Julien; Chauvin, Anne-Sophie
Physical Chemistry Chemical Physics, 2013 , vol. 15, # 38 p. 15981 - 15994
反应条件
1: pyridine; piperidine
2: aluminium chloride; sodium chloride / 150 °C
3: ethanol; aqueous hydrochloric acid / Behandeln des Reaktionsprodukts mit Wasser
View Scheme
参考文献
Veres et al.
Collection of Czechoslovak Chemical Communications, 1959 , vol. 24, p. 3471,3474
反应条件
1: hydriodic acid; acetic anhydride; acetic acid / 1 h / 80 °C
2: HCl / 1.5 h / Heating
View Scheme
参考文献
Andres, Julien; Chauvin, Anne-Sophie
Physical Chemistry Chemical Physics, 2013 , vol. 15, # 38 p. 15981 - 15994
反应条件
potassium carbonate; potassium iodide in acetone
1. 0.5h reflux 2. 8h reflux;
参考文献
Shridhar, D. R.; Ram, Bhagat; Sarma, C. R.; Sachdeva, Y. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. <B> 22, # 8 p. 835 - 836
反应条件
ammonium acetate in toluene
T=130°C;
参考文献
Peng, Shiyong; Wang, Lei; Huang, Jiayao; Sun, Shaofa; Guo, Haibing; Wang, Jian
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 13 p. 2550 - 2557
反应条件
pyridine in chloroform
T=60°C; 16 h;
参考文献
Barton, Derek H. R.; Donnelly, Dervilla M. X.; Finet, Jean-Pierre; Guiry, Patrick J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , p. 1365 - 1376
