2,5-二甲氧基苯基乙酸合成路线 （共 35 条）
反应条件
diborane in tetrahydrofuran
参考文献
Nichols; Snyder; Oberlender; Johnson; Huang
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 276 - 281
反应条件
1: thionyl chloride / benzene / 3 h / Heating
2: 77 percent / pyridine / 8 h / Heating
3: 50 percent / boron tribromide / CH2Cl2 / 1)8h -80 deg C 2)3h room temp.
View Scheme
参考文献
Kong, Josephine L. Y.; Loach, Paul A.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 737 - 744
反应条件
1.1: SOCl2 / CH2Cl2 / Heating
2.1: DIEA / CH2Cl2 / 4 h / 0 - 20 °C
2.2: 94 percent / 2 h / Heating
View Scheme
参考文献
Terai, Takuya; Kikuchi, Kazuya; Iwasawa, Shin-Ya; Kawabe, Takao; Hirata, Yasunobu; Urano, Yasuteru; Nagano, Tetsuo
Journal of the American Chemical Society, 2006 , vol. 128, # 21 p. 6938 - 6946
反应条件
1: 100 percent / diborane / tetrahydrofuran
2: PBr3
View Scheme
参考文献
Green et al.
Journal of the Chemical Society, 1959 , p. 3362,3369
反应条件
1: 92 percent / Br2 / acetic acid / 2 h / 25 °C
2: 85 percent / BH3 / tetrahydrofuran / 8 h / 0 - 25 °C
3: 62 percent / boron tribromide / CH2Cl2 / 22.5 h / Ambient temperature
4: potassium carbonate / acetone / 18 h / Heating
View Scheme
参考文献
Waldman, Steve R.; Monte, Aaron P.; Bracey, Ann; Nichols, David E.
Tetrahedron Letters, 1996 , vol. 37, # 44 p. 7889 - 7892
