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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
缬更昔洛韦盐酸盐
合成路线
（共 10 条）
194154-40-0
Cbz-缬更昔洛韦
→
反应条件
175865-59-5
缬更昔洛韦盐酸盐
反应条件
hydrogenchloride; hydrogen; palladium on carbon in water; isopropyl alcohol T=25 - 40°C; P=367.786 - 735.572 Torr; 1 h; Product distribution / selectivity;
参考文献
RANBAXY LABORATORIES LIMITED; HASHMI, Mohammed, Salman; SHARMA, Mukesh, Kumar; KHANDURI, Chandra, Has
Patent: WO2011/18771 A2, 2011 ;
Location in patent: Page/Page column 9-10 ;
175865-55-1
→
反应条件
175865-59-5
缬更昔洛韦盐酸盐
反应条件
hydrogenchloride; hydrogen; 5 palladium on charcoal in methanol; water P=5171.62 - 7757.43 Torr; Inert atmosphere;
参考文献
PHARMATHEN S.A.; KOFTIS, Theocharis, V.; GEORGOPOULOU, Ioanna; VARVOGLI, Anastasia, Aikaterini; ZITROU, Asteria
Patent: WO2012/163373 A1, 2012 ;
Location in patent: Page/Page column 10 ;
1219792-38-7
→
反应条件
175865-59-5
缬更昔洛韦盐酸盐
反应条件
hydrogenchloride; palladium 10 on activated carbon; hydrogen in methanol; water P=2942.29 Torr; 2 h; Autoclave;
参考文献
Babu, K. Srihari; Srinivas; Madhavi; Babu; Reddy, G. Madhusudhan; Haldar; Rao, P. Narasimha; Krishna; Venkateshwarulu; Reddy, P. Pratap; Anand, R. Vijaya
Arkivoc, 2011 , vol. 2011, # 2 p. 199 - 208
72-18-4
L-缬氨酸
+
1219792-46-7
→
反应条件
175865-59-5
缬更昔洛韦盐酸盐
反应条件
tetrabutylammomium bromide; sodium hydroxide in N,N-dimethyl-formamide T=20 - 93°C;
参考文献
WO2010/36904 A2, ;
Page/Page column 51 ;
82410-32-0
更昔洛韦
→
反应条件
175865-59-5
缬更昔洛韦盐酸盐
反应条件
1.1: benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide 2.1: zinc / isopropyl alcohol / 5 - 30 °C 3.1: acetic acid; trifluoroacetic acid / isopropyl alcohol / 0.08 h 3.2: 0.5 h View Scheme
参考文献
Arkivoc, , vol. 2011, # 2 p. 199 - 208
72-18-4
L-缬氨酸
→
反应条件
175865-59-5
缬更昔洛韦盐酸盐
反应条件
1.1: imidazole sulfonyl azide 2.1: benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide 3.1: zinc / isopropyl alcohol / 5 - 30 °C 4.1: acetic acid; trifluoroacetic acid / isopropyl alcohol / 0.08 h 4.2: 0.5 h View Scheme
参考文献
Arkivoc, , vol. 2011, # 2 p. 199 - 208
40224-47-3
→
反应条件
175865-59-5
缬更昔洛韦盐酸盐
反应条件
1.1: benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide 2.1: zinc / isopropyl alcohol / 5 - 30 °C 3.1: acetic acid; trifluoroacetic acid / isopropyl alcohol / 0.08 h 3.2: 0.5 h View Scheme
参考文献
Arkivoc, , vol. 2011, # 2 p. 199 - 208
1219792-43-4
→
反应条件
175865-59-5
缬更昔洛韦盐酸盐
反应条件
1.1: trifluoroacetic acid / dichloromethane / 3.17 h / 15 °C 2.1: zinc / isopropyl alcohol / 5 - 30 °C 3.1: acetic acid; trifluoroacetic acid / isopropyl alcohol / 0.08 h 3.2: 0.5 h View Scheme
参考文献
Arkivoc, , vol. 2011, # 2 p. 199 - 208
109082-85-1
→
反应条件
175865-59-5
缬更昔洛韦盐酸盐
反应条件
1.1: dicyclohexyl-carbodiimide / dichloromethane / 0.5 h / 0 °C 1.2: 17 h / 25 °C 2.1: trifluoroacetic acid / dichloromethane / 3.17 h / 15 °C 3.1: zinc / isopropyl alcohol / 5 - 30 °C 4.1: acetic acid; trifluoroacetic acid / isopropyl alcohol / 0.08 h 4.2: 0.5 h View Scheme
参考文献
Arkivoc, , vol. 2011, # 2 p. 199 - 208
175865-68-6
→
反应条件
175865-59-5
缬更昔洛韦盐酸盐
反应条件
1: With acetic acid; trifluoroacetic acid in isopropyl alcohol 0.0833333 h; 2: With hydrogenchloride in water; isopropyl alcohol 0.5 h;
参考文献
Babu, K. Srihari; Srinivas; Madhavi; Babu; Reddy, G. Madhusudhan; Haldar; Rao, P. Narasimha; Krishna; Venkateshwarulu; Reddy, P. Pratap; Anand, R. Vijaya
Arkivoc, 2011 , vol. 2011, # 2 p. 199 - 208
