4-甲氧基-3-甲基苯硼酸合成路线 （共 5 条）
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-50°C; 0.25 h; 2: With boric acid trimethyl ester in tetrahydrofuran; hexane T=20°C; 3: With hydrogenchloride in tetrahydrofuran; hexane T=0°C; 1 h;
参考文献
Journal of the American Chemical Society, , vol. 125, # 36 p. 10977 - 10996
反应条件
1: With boric acid trimethyl ester in tetrahydrofuran T=-78 - 20°C; 2: With hydrogenchloride in tetrahydrofuran Further stages.;
参考文献
Steele, Melanie; Watkinson, Michael; Whiting, Andrew
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 6 p. 588 - 598
反应条件
caesium carbonate; tetrakis (triphenylphosphine) palladium (0) in water; ethyl acetate; toluene
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US2003/153556 A1, 2003 ;
US 20030153556 A1
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane; water
2 h; Heating / reflux;
参考文献
4 AZA Bioscience nv
Patent: WO2006/135993 A1, 2006 ;
Location in patent: Page/Page column 72 ;
反应条件
1: Pd(PPh3)4; aq. Na2CO3 / ethanol; benzene
2: BBr3 / CH2Cl2
View Scheme
参考文献
Gfesser, Gregory A.; Faghih, Ramin; Bennani, Youssef L.; Curtis, Michael P.; Esbenshade, Timothy A.; Hancock, Arthur A.; Cowart, Marlon D.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2559 - 2563
