1: anhydrous cyanoacetic acid With isopropylmagnesium chloride in tetrahydrofuran; dichloromethane 2: cyclopropanecarboxylic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran; dichloromethane T=20°C; 60 h; 3: With hydrogenchloride; water in tetrahydrofuran; dichloromethane T=0°C; 1 h;
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2005/90313 A1, 2005 ;
Location in patent: Page/Page column 136-137 ;
1: cyclopropanecarboxylic acid With triethylamine in hexane; dichloromethane 1 h; Cooling with ice; 2: cyclopropionyl chloride in hexane; dichloromethane T=20°C; 2.16667 h; Cooling with ice;
参考文献
MacHara, Ales; Werner, Lukas; Endoma-Arias, Mary Ann; Cox, D. Phillip; Hudlicky, Tomas
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 4 p. 613 - 626
4-methyl-morpholine in dichloromethane T=20°C; 2 h;
参考文献
Rolfe, Alan; Probst, Donald A.; Volp, Kelly A.; Omar, Iman; Flynn, Daniel L.; Hanson, Paul R.
Journal of Organic Chemistry, 2008 , vol. 73, # 22 p. 8785 - 8790