catalyst 1 (aliphatic, phosphine based pincer complex of palladium) in 1,4-dioxane; 1-methyl-pyrrolidin-2-one T=100°C; Negishi cross-coupling reaction; 1 h;

ammonia T=20°C;

1: thiophen-2-yl-MgX, X = halide With zinc(II) chloride in tetrahydrofuran T=25°C; 0.25 h; Inert atmosphere; 2: (3-bromophenyl)acetic acid methyl ester With [(C10H13-1,3-(CH2P(Cy)2)2)Pd(Cl)] in tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one T=100°C; Negishi cross-coupling reaction; Inert atmosphereResealed tube;

sodium hydroxide; water in tetrahydrofuran; methanol T=60°C; 2 h;