3,6,9,12,15,18,21,24,27,30,33,36-十二氧杂三十八烷-1,38-二醇合成路线 （共 7 条）
→
17598-96-83,6,9,12,15,18,21,24,27,30,33,36-十二氧杂三十八烷-1,38-二醇
反应条件
hydrogen; palladium on activated charcoal in methanol P=10343 Torr;
参考文献
Andrus, Merritt B.; Turner, Timothy M.; Updegraff, Emily P.; Sauna, Zuben E.; Ambudkar, Suresh V.
Tetrahedron Letters, 2001 , vol. 42, # 23 p. 3819 - 3822
→
17598-96-83,6,9,12,15,18,21,24,27,30,33,36-十二氧杂三十八烷-1,38-二醇
反应条件
1: 1.) NaH / 1.) THF, 0.5 h, 2.) a) reflux, 3 h, b) RT, 12 h 2: conc. HCl, p-toluenesulfonic acid / methanol / 12 h View Scheme
参考文献
Jayasuriya, Nimal; Bosak, Stanislav; Regen, Steven L.
Journal of the American Chemical Society, 1990 , vol. 112, # 15 p. 5851 - 5854
→
17598-96-83,6,9,12,15,18,21,24,27,30,33,36-十二氧杂三十八烷-1,38-二醇
反应条件
1: 1.) NaH / 1.) THF, 0.5 h, 2.) a) reflux, 3 h, b) RT, 12 h 2: conc. HCl, p-toluenesulfonic acid / methanol / 12 h View Scheme
参考文献
Jayasuriya, Nimal; Bosak, Stanislav; Regen, Steven L.
Journal of the American Chemical Society, 1990 , vol. 112, # 15 p. 5851 - 5854
→
17598-96-83,6,9,12,15,18,21,24,27,30,33,36-十二氧杂三十八烷-1,38-二醇
反应条件
1: 81 percent / NaOH / H2O / Heating 2: 59 percent / NaH / tetrahydrofuran / Heating 3: 77 percent / H2 / Pd/C 10 percent / methanol / 10343 Torr View Scheme
参考文献
Andrus, Merritt B.; Turner, Timothy M.; Updegraff, Emily P.; Sauna, Zuben E.; Ambudkar, Suresh V.
Tetrahedron Letters, 2001 , vol. 42, # 23 p. 3819 - 3822
→
17598-96-83,6,9,12,15,18,21,24,27,30,33,36-十二氧杂三十八烷-1,38-二醇
反应条件
1: 59 percent / NaH / tetrahydrofuran / Heating 2: 77 percent / H2 / Pd/C 10 percent / methanol / 10343 Torr View Scheme
参考文献
Andrus, Merritt B.; Turner, Timothy M.; Updegraff, Emily P.; Sauna, Zuben E.; Ambudkar, Suresh V.
Tetrahedron Letters, 2001 , vol. 42, # 23 p. 3819 - 3822
→
17598-96-83,6,9,12,15,18,21,24,27,30,33,36-十二氧杂三十八烷-1,38-二醇
反应条件
1: 59 percent / NaH / tetrahydrofuran / Heating 2: 77 percent / H2 / Pd/C 10 percent / methanol / 10343 Torr View Scheme
参考文献
Andrus, Merritt B.; Turner, Timothy M.; Updegraff, Emily P.; Sauna, Zuben E.; Ambudkar, Suresh V.
Tetrahedron Letters, 2001 , vol. 42, # 23 p. 3819 - 3822
→
17598-96-83,6,9,12,15,18,21,24,27,30,33,36-十二氧杂三十八烷-1,38-二醇
反应条件
1: 97 percent / trietylamine / CH2Cl2 2: 59 percent / NaH / tetrahydrofuran / Heating 3: 77 percent / H2 / Pd/C 10 percent / methanol / 10343 Torr View Scheme
参考文献
Andrus, Merritt B.; Turner, Timothy M.; Updegraff, Emily P.; Sauna, Zuben E.; Ambudkar, Suresh V.
Tetrahedron Letters, 2001 , vol. 42, # 23 p. 3819 - 3822
