N-Boc-N′-Fmoc-二氨基乙酸合成路线 （共 7 条）
反应条件
1: 2-[N-[[(9-fluorenyl)methoxy]carbonyl]amino]-2-(isopropylthio)acetic acid With N-bromosuccinmide in tetrahydrofuran T=0°C; 0.5 h; 2: carbamic acid 1,1-dimethylethyl ester in tetrahydrofuran T=0°C; 12 h; Further stages.;
参考文献
Yaouancq, Loic; Rene, Loic; Tran Huu Dau, Marie-Elise; Badet, Bernard
The Journal of organic chemistry, 2002 , vol. 67, # 15 p. 5408 - 5411
反应条件
1.1: N-bromosuccinimide / tetrahydrofuran / 0.5 h / 0 °C 1.2: 82 percent / tetrahydrofuran / 12 h / 0 °C View Scheme
参考文献
The Journal of organic chemistry, , vol. 67, # 15 p. 5408 - 5411
反应条件
1: aq. ammonium hydroxide / dioxane / 1 h / 0 °C 2: 82 percent / H2O; toluene / Heating 3: 60 percent / N-bromosuccinimide / tetrahydrofuran / 1.) 0 deg C, 20 min, 2.) reflux, 2h View Scheme
参考文献
Synthetic Communications, , vol. 26, # 17 p. 3237 - 3239
反应条件
1: diethyl ether / Ambient temperature 2: N-bromo-succinimide / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 34, # 24 p. 3861 - 3862
反应条件
N-bromosuccinmide in tetrahydrofuran 2 h; Heating; Yield given;
参考文献
Tetrahedron Letters, , vol. 34, # 24 p. 3861 - 3862
反应条件
1: aq. ammonium hydroxide / dioxane / 1 h / 0 °C 2: 82 percent / H2O; toluene / Heating 3: 60 percent / N-bromosuccinimide / tetrahydrofuran / 1.) 0 deg C, 20 min, 2.) reflux, 2h View Scheme
参考文献
Synthetic Communications, , vol. 26, # 17 p. 3237 - 3239
反应条件
1.1: K2CO3 / dimethylformamide / 0.17 h / 20 °C 1.2: dimethylformamide / 0 - 20 °C 2.1: papain; water / dimethylformamide; acetonitrile / 37 °C / pH 6.2 View Scheme
参考文献
Sypniewski, Michal; Penke, Botond; Simon, Lajos; Rivier, Jean
Journal of Organic Chemistry, 2000 , vol. 65, # 20 p. 6595 - 6600
