3-氧代-6-庚烯酸乙基合成路线 （共 15 条）
反应条件
1: 1.) hydroxylamine hydrochloride, sodium acetate, 2.) aq. hydrochloric acid / 1.) water, ethanol, 80 deg C, 3 h, 2.) ethanol, reflux, 30 min
2: sodium, isopropanol
3: hydrogen chloride / 48 h / Ambient temperature
4: 33 percent / o-tolylmagnesium bromide / diethyl ether; CH2Cl2 / 48 h / Ambient temperature
View Scheme
参考文献
Shibuya, Masayuki; Kubota, Seiju
Heterocycles, 1980 , vol. 14, # 5 p. 601 - 609
反应条件
1: 3-oxo-hept-6-enoic acid ethyl ester With sodium hydroxide
T=15°C; 18 h;
2: pyruvic aldehyde With sodium dithionite; sodium hydrogencarbonate
T=20°C; pH=8.0 - 8.5;
参考文献
Kato, Takeaki; Mochizuki, Masao; Okano, Shigeru; Matsuo, Noritada
Synthetic Communications, 2003 , vol. 33, # 22 p. 3977 - 3982
反应条件
1.1: 65 percent / NaH / dimethylformamide / 20 h / 70 °C
2.1: water; sodium hydroxide / 1 h / 20 °C
2.2: aq. hydrochloric acid / 1 h
View Scheme
参考文献
Tiecco, Marcello; Testaferri, Lorenzo; Bagnoli, Luana; Scarponi, Catalina; Temperini, Andrea; Marini, Francesca; Santi, Claudio
Tetrahedron Asymmetry, 2006 , vol. 17, # 19 p. 2768 - 2774
反应条件
chloro-trimethyl-silane; dichloro bis(acetonitrile) palladium(II) in 1,4-dioxane
T=25°C; 20 h;
参考文献
Han, Xiaoqing; Wang, Xiang; Pei, Tao; Widenhoefer, Ross A.
Chemistry - A European Journal, 2004 , vol. 10, # 24 p. 6333 - 6342
反应条件
1: 69 percent / TiCl4; pyridine / tetrahydrofuran / 0 - 20 °C
2: 82 percent / Grubbs catalyst 2nd generation / CH2Cl2 / 0.5 h / Heating
View Scheme
参考文献
Toueg, Julie; Prunet, Joelle
Synlett, 2006 , # 17 p. 2807 - 2811
