反应条件
1.1: sodium carbonate; sodium iodide / ethanol; water / 3 h / 22 °C / Inert atmosphere; Reflux; Large scale reaction 1.2: Inert atmosphere 2.1: sulfuric acid / cyclohexane / 77 - 83 °C / Inert atmosphere; Large scale reaction 3.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -75 °C / Large scale reaction 3.2: 3 h / -75 - -10 °C / Enzymatic reaction 3.3: 4 h / 40 °C / Enzymatic reaction View Scheme
参考文献
Berwe, Mathias; Joentgen, Winfried; Krueger, Jochen; Cancho-Grande, Yolanda; Lampe, Thomas; Michels, Martin; Paulsen, Holger; Raddatz, Siegfried; Weigand, Stefan
Organic Process Research and Development, 2011 , vol. 15, # 6 p. 1348 - 1357