反应条件
1: methanol / 2 h / 20 °C 2: sodium tetrahydroborate / methanol / 0.5 h 3: sodium hydroxide / methanol / 1 h 4: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 0 - 20 °C 5: tri-isopropoxy-borane; n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C 6: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; triethylamine / water; ethylene glycol dimethyl ether / 4 h / 90 °C 7: hydrogenchloride / 1,4-dioxane / 20 °C 8: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C View Scheme
参考文献
Takeuchi, Craig S.; Kim, Byung Gyu; Blazey, Charles M.; Ma, Sunghoon; Johnson, Henry W. B.; Anand, Neel K.; Arcalas, Arlyn; Baik, Tae Gon; Buhr, Chris A.; Cannoy, Jonah; Epshteyn, Sergey; Joshi, Anagha; Lara, Katherine; Lee, Matthew S.; Wang, Longcheng; Leahy, James W.; Nuss, John M.; Aay, Naing; Aoyama, Ron; Foster, Paul; Lee, Jae; Lehoux, Isabelle; Munagala, Narsimha; Plonowski, Arthur; Rajan, Sharmila; Woolfrey, John; Yamaguchi, Kyoko; Lamb, Peter; Miller, Nicole
Journal of Medicinal Chemistry, 2013 , vol. 56, # 6 p. 2218 - 2234