反应条件
1: K2CO3 / acetone / 18.5 h / 20 - 50 °C
2: aq. 8percent NaOH / methanol / 1 h
3: 1.) Ac2O, NaOAc, 2.) H2O / 1.) AcOH, reflux, 1 h, 2.) AcOH, reflux, 1 h
View Scheme
参考文献
GLAXOSMITHKLINE LLC; ADAMS, Nicholas, D.; AQUINO, Christopher, Joseph; CHAUDHARI, Amita, M.; GHERGUROVICH, Jonathan, M.; KIESOW, Terence, John; PARRISH, Cynthia, A.; REIF, Alexander, Joseph; WIGGALL, Kenneth
Patent: WO2011/103546 A1, 2011 ;
WO 2011/103546 A1