反应条件
1: 100 percent / K2CO3, NaI / dimethylformamide / 15 h / Ambient temperature 2: 1.) MeONa, 2.) HCl gas / 1.) reflux, 15 min, 2.) RT, 2 h 3: 90 percent / CuI / dimethylformamide / 16 h / 155 °C 4: 53 percent / 5 N aq. NaOH / ethanol / 3 h / Heating View Scheme
参考文献
Sall, Daniel J.; Arfsten, Ann E.; Bastian, Jolie A.; Denney, Michael L.; Harms, Cathy S.; McCowan, Jefferson R.; Morin Jr., John M.; Rose, Jack W.; Scarborough, Robert M.; Smyth, Mark S.; Um, Suzane L.; Utterback, Barbara G.; Vasileff, Robert T.; Wikel, James H.; Wyss, Virginia L.; Jakubowski, Joseph A.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 18 p. 2843 - 2857
