3,5-双(叔丁基)苯甲醛合成路线 （共 43 条）
反应条件
1: 1-bromo-3,5-di-tert-butylbenzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.333333 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=-78 - 20°C; 1.33333 h; Inert atmosphere; 3: With water in tetrahydrofuran; hexane
参考文献
Ebner, Christian; Mueller, Constanze A.; Markert, Christian; Pfaltz, Andreas
Journal of the American Chemical Society, 2011 , vol. 133, # 13 p. 4710 - 4713
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine in dichloromethane T=-78 - 20°C;
参考文献
Zehnder II, Donald W.; Smithrud, David B.
Organic Letters, 2001 , vol. 3, # 16 p. 2485 - 2487
反应条件
lithium tri-t-butoxyaluminum hydride in tetrahydrofuran 1.) -78 deg C, 0.5 h; 2.) r.t., 2 h;
参考文献
Katsumi; Kondo; Yamashita; Hidaka; Hosoe; Watanabe
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 1 p. 121 - 129
反应条件
pyridine; hydrogen; palladium diacetate; 1,3-bis-(diphenylphosphino)propane in N,N-dimethyl-formamide T=100°C; P=15001.5 Torr; 24 h;
参考文献
Brennfuhrer, Anne; Neumann, Helfried; Beller, Matthias
Synlett, 2007 , # 16 p. 2537 - 2540
反应条件
1: With N-bromosuccinmide in benzene 16 h; RefluxIrradiation; 2: With 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in ethanol; water 4 h; Reflux; 3: With hydrogenchloride in ethanol; water 0.5 h; Reflux;
参考文献
Newman, Stephen G.; Lautens, Mark
Journal of the American Chemical Society, 2010 , vol. 132, # 33 p. 11416 - 11417
反应条件
TiCl4 in dichloromethane
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
hydrogen; palladium on barium sulfate in xylene
参考文献
Journal of the American Chemical Society, , vol. 82, p. 6188 - 6193
反应条件
sodium hydroxide; manganese(IV) dioxide in tetrahydrofuran; chloroform
反应条件
1: With 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in methanol; water 4 h; Heating; 2: With hydrogenchloride in methanol 0.5 h; Heating;
参考文献
Plater, M.John; Aiken, Stuart; Bourhill, Grant
Tetrahedron, 2002 , vol. 58, # 12 p. 2405 - 2413
参考文献
Risch, Nikolaus; Meyer-Roscher, Bernd; Langhals, Maria
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1994 , vol. 49, # 1 p. 141 - 144
