(1-甲基乙基)氨基甲酸苯基酯合成路线 （共 10 条）
反应条件
1: in n-heptane T=0 - 4°C; 1 h; 2: in n-heptane; water T=0 - 70°C;
参考文献
FINETECH LABORATORIES LTD.
Patent: WO2003/97603 A1, 2003 ;
Location in patent: Page/Page column 30 ;
反应条件
triethylamine in dichloromethane T=23°C; 2 h; Inert atmosphere;
参考文献
Bronner, Sarah M.; Garg, Neil K.
Journal of Organic Chemistry, 2009 , vol. 74, # 22 p. 8842 - 8843
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in N,N-dimethyl-formamide 45 h; Ambient temperature;
参考文献
Boontheung, Pinmanee; Perlmutter, Patrick
Tetrahedron Letters, 1998 , vol. 39, # 17 p. 2629 - 2630
参考文献
FMC Corporation
Patent: US4123450 A1, 1978 ;
反应条件
in benzene a.) RT, 1 h, b.) reflux, 1 h;
参考文献
Patonay, Tamas; Patonay-Peli, Erzsebet; Mogyorodi, Ferenc
Synthetic Communications, 1990 , vol. 20, # 18 p. 2865 - 2885
反应条件
1: 88.6 percent / Et3N / CH2Cl2 / 1.67 h / 5 °C 2: 55.8 percent / benzene / a.) RT, 1 h, b.) reflux, 1 h View Scheme
参考文献
Patonay, Tamas; Patonay-Peli, Erzsebet; Mogyorodi, Ferenc
Synthetic Communications, 1990 , vol. 20, # 18 p. 2865 - 2885
反应条件
1.1: TMSOTf; TMEDA / diethyl ether / 0.5 h / 0 - 25 °C 1.2: TMEDA; n-BuLi / diethyl ether / 1 h / -78 °C 1.3: 75 percent / I2 / diethyl ether; tetrahydrofuran / 2 h / -78 °C 2.1: aq. NaOH / ethanol / 2 h View Scheme
参考文献
Ganta, Ashok; Snowden, Timothy S.
Synlett, 2007 , # 14 p. 2227 - 2231
反应条件
1: With triethylamine in water; acetone 3 h; Heating / reflux; 2: With sodium hydroxide in water T=20 - 25°C; 3: With sulfuric acid in water; acetone T=50 - 55°C; 1 h; Product distribution / selectivity;
参考文献
FINETECH LABORATORIES LTD.
Patent: WO2003/97603 A1, 2003 ;
Location in patent: Page/Page column 46-47 ;
反应条件
1.1: TMSOTf; TMEDA / diethyl ether / 0.5 h / 0 - 25 °C 1.2: TMEDA; n-BuLi / diethyl ether / 1 h / -78 °C 1.3: 75 percent / I2 / diethyl ether; tetrahydrofuran / 2 h / -78 °C 2.1: 93 percent / DIPEA / CH2Cl2 / -78 - 25 °C View Scheme
参考文献
Synlett, , # 14 p. 2227 - 2231
反应条件
1: TMEDA / diethyl ether; pentane / 0.5 h / 20 °C
2: sec-butyllithium; TMEDA / diethyl ether; pentane / 2 h / -78 °C
3: 0.318 g / aq. HCl / methanol / -78 - 20 °C
4: 96 percent / ICl / CH2Cl2 / 3 h / 0 - 20 °C
5: 97 percent / aq. NaOH / ethanol; tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Kauch, Matthias; Hoppe, Dieter
Synthesis, 2006 , # 10 p. 1578 - 1589
