反应条件
1: W-2 Raney nickel / ethanol / 48 h / -60 °C
2: NH4F / ethanol / 26 h / 65 °C
3: PCC, NaOAc, silica / CH2Cl2 / 4 h / 0 - 20 °C
4: 1.) NaH / 1.) THF, 0 deg C, 30 min, 2.) THF, from 0 deg C to RT, 2 h
5: 85 percent / potassium trimethylsilanolate / CH2Cl2 / Ambient temperature
6: Et3N / N,N-dimethyl-acetamide / 3 h / Ambient temperature
7: Et3N / 24 h / Ambient temperature
View Scheme
参考文献
Barrett, Anthony G. M.; Kasdorf, Krista
Chemical Communications, 1996 , # 3 p. 325 - 326
