3-吡啶甲烷硫醇(6ci,7ci,8ci,9ci)合成路线 （共 14 条）
反应条件
1: aq. NaOH
2: t-BuOK / tetrahydrofuran; hexamethylphosphoric acid triamide / Ambient temperature
View Scheme
参考文献
Aloup, Jean-Claude; Bouchaudon, Jean; Farge, Daniel; James, Claude; Deregnaucourt, Jean; Hardy-Houis, Monique
Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 24 - 29
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in dichloromethane
Ambient temperature;
参考文献
Brown, Thomas J.; Chapman, Robert F.; Cook, David C.; Hart, Terance W.; McLay, Iain M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 20 p. 3613 - 3624
反应条件
1: aq. NaOH
2: t-BuOK / tetrahydrofuran; hexamethylphosphoric acid triamide / Ambient temperature
3: 1.) BuLi
View Scheme
参考文献
Aloup, Jean-Claude; Bouchaudon, Jean; Farge, Daniel; James, Claude; Deregnaucourt, Jean; Hardy-Houis, Monique
Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 24 - 29
反应条件
1: 68 percent / triethylbenzylammonium chloride, 10 N aq. NaOH / CH2Cl2 / Ambient temperature
2: m-chloroperoxybenzoic acid / CH2Cl2 / Ambient temperature
View Scheme
参考文献
Brown, Thomas J.; Chapman, Robert F.; Cook, David C.; Hart, Terance W.; McLay, Iain M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 20 p. 3613 - 3624
