1: 83 percent / NaBH4 / methanol / 4 h / Ambient temperature 2: 1.) Et3N, 2.) H2O / 1.) CH2Cl2, 0-5 deg C, 4 h, 2.) RT, 30 min 3: 68 percent / ethanol; CHCl3 / 60 h / 60 - 70 °C 4: H2 / 10percent Pd/C / CHCl3; methanol / 4 h / Ambient temperature View Scheme

1: 83 percent / NaBH4 / methanol / 4 h / Ambient temperature 2: 1.) Et3N, 2.) H2O / 1.) CH2Cl2, 0-5 deg C, 4 h, 2.) RT, 30 min 3: 68 percent / ethanol; CHCl3 / 60 h / 60 - 70 °C 4: H2 / 10percent Pd/C / CHCl3; methanol / 4 h / Ambient temperature View Scheme