4-溴-5-(氯磺酰基)-2-甲基苯甲酸合成路线 （共 3 条）
反应条件
hydrogenchloride; sodium hydroxide in water; N,N-dimethyl-formamide; acetone; toluene
参考文献
Hoechst Aktiengesellschaft
Patent: US6057322 A1, 2000 ;
反应条件
1: aq. Na2SO3, aq. NaOH / 15 - 20 °C 2: K2CO3 / dimethylformamide / Ambient temperature View Scheme
参考文献
Baumgarth, Manfred; Beier, Norbert; Gericke, Rolf
Journal of Medicinal Chemistry, 1997 , vol. 40, # 13 p. 2017 - 2034
反应条件
chlorosulfonic acid
T=0 - 100°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG; BENTZIEN, Joerg, Martin; BOYER, Stephen, James; BURKE, Jennifer; ELDRUP, Anne, Bettina; GUO, Xin; HUBER, John, David; KIRRANE, Thomas, Martin; SOLEYMANZADEH, Fariba; SWINAMER, Alan, David
Patent: WO2010/5783 A1, 2010 ;
Location in patent: Page/Page column 94 ;
WO 2010/005783 A1
