N-boc-2-乙烯基吡咯烷合成路线 （共 4 条）
反应条件
1: Methyltriphenylphosphonium bromide With potassium tert-butylate in diethyl ether 1 h; Heating; 2: (R)-2-formyl-1-pyrrolidinecarboxylic acid,1,1-dimethylethyl ester in diethyl ether T=20°C; Wittig olefination;
参考文献
Molander, Gary A.; Romero, Jan Antoinette C.
Tetrahedron, 2005 , vol. 61, # 10 p. 2631 - 2643
反应条件
sodium hydride in dimethyl sulfoxide Racemization; Wittig olefination;
参考文献
Ikeda, Masazumi; Shikaura, Jiro; Maekawa, Noriko; Daibuzono, Kaori; Teranishi, Hirotaka; Teraoka, Yoshiko; Oda, Norio; Ishibashi, Hiroyuki
Heterocycles, 1999 , vol. 50, # 1 p. 31 - 34
反应条件
1: With sodium hydroxide; dihydrogen peroxide; bis-(1,2-dimethylpropyl)borane in tetrahydrofuran Oxidation; 2: With oxalyl dichloride; triethylamine in dichloromethane; dimethyl sulfoxide Oxidation;
参考文献
Ikeda, Masazumi; Shikaura, Jiro; Maekawa, Noriko; Daibuzono, Kaori; Teranishi, Hirotaka; Teraoka, Yoshiko; Oda, Norio; Ishibashi, Hiroyuki
Heterocycles, 1999 , vol. 50, # 1 p. 31 - 34
反应条件
1.1: dichloromethane / 20 °C
2.1: potassium hydroxide / ethanol / 0.5 h / 20 °C
2.2: 15 h / 20 °C
3.1: n-butyllithium; N,N,N',N,-tetramethylethylenediamine / tetrahydrofuran; hexane / -78 - 20 °C
View Scheme
参考文献
Garcia-Calvo, Oihane; Sotomayor, Nuria; Lete, Esther; Coldham, Iain
Arkivoc, 2011 , vol. 2011, # 5 p. 57 - 66
