1-(对甲苯磺酰基)吡咯合成路线 （共 50 条）
反应条件
1: 69 percent / ClSCN / acetic acid / 0.5 h / Ambient temperature
2: 94 percent / 1N NaOH / 2-methyl-propan-2-ol / 2.5 h / Ambient temperature
3: 96 percent / 2N NaOH / ethanol / 1 h / Ambient temperature
View Scheme
参考文献
Kakushima, Masatoshi; Frenette, Richard
Journal of Organic Chemistry, 1984 , vol. 49, # 11 p. 2025 - 2027
反应条件
1: 69 percent / ClSCN / acetic acid / 0.5 h / Ambient temperature
2: 96 percent / 1N NaOH / 2-methyl-propan-2-ol / 2.5 h / Ambient temperature
View Scheme
参考文献
Kakushima, Masatoshi; Frenette, Richard
Journal of Organic Chemistry, 1984 , vol. 49, # 11 p. 2025 - 2027
反应条件
1: 69 percent / ClSCN / acetic acid / 0.5 h / Ambient temperature
2: 98 percent / 1N NaOH / 2-methyl-propan-2-ol / 2.5 h / Ambient temperature
View Scheme
参考文献
Kakushima, Masatoshi; Frenette, Richard
Journal of Organic Chemistry, 1984 , vol. 49, # 11 p. 2025 - 2027
反应条件
n-butyllithium
1) THF, hexane, -15 deg C, 5 min, 2) THF, -40 deg C, 1h; Yield given. Multistep reaction;
参考文献
Kakushima, Masatoshi; Frenette, Richard
Journal of Organic Chemistry, 1984 , vol. 49, # 11 p. 2025 - 2027
反应条件
1: 69 percent / ClSCN / acetic acid / 0.5 h / Ambient temperature
2: 1N NaOH / methanol / 2.5 h / Ambient temperature
3: 55 percent / trifluoroacetic acid / 1,2-dichloro-ethane / 2.5 h / Heating
View Scheme
参考文献
Kakushima, Masatoshi; Frenette, Richard
Journal of Organic Chemistry, 1984 , vol. 49, # 11 p. 2025 - 2027
反应条件
1: 69 percent / ClSCN / acetic acid / 0.5 h / Ambient temperature
2: 94 percent / 1N NaOH / 2-methyl-propan-2-ol / 2.5 h / Ambient temperature
3: 96 percent / 2N NaOH / ethanol / 1 h / Ambient temperature
4: 83 percent / trifluoroacetic acid / 1,2-dichloro-ethane / 4 h / Heating
View Scheme
参考文献
Kakushima, Masatoshi; Frenette, Richard
Journal of Organic Chemistry, 1984 , vol. 49, # 11 p. 2025 - 2027
反应条件
1: 69 percent / ClSCN / acetic acid / 0.5 h / Ambient temperature
2: 96 percent / 1N NaOH / 2-methyl-propan-2-ol / 2.5 h / Ambient temperature
3: 85 percent / trifluoroacetic acid / 1,2-dichloro-ethane / 2.5 h / Heating
View Scheme
参考文献
Kakushima, Masatoshi; Frenette, Richard
Journal of Organic Chemistry, 1984 , vol. 49, # 11 p. 2025 - 2027
反应条件
1: 69 percent / ClSCN / acetic acid / 0.5 h / Ambient temperature
2: 98 percent / 1N NaOH / 2-methyl-propan-2-ol / 2.5 h / Ambient temperature
3: 84 percent / trifluoroacetic acid / 1,2-dichloro-ethane / 2.5 h / Heating
View Scheme
参考文献
Kakushima, Masatoshi; Frenette, Richard
Journal of Organic Chemistry, 1984 , vol. 49, # 11 p. 2025 - 2027
反应条件
1: 1) n-BuLi / 1) THF, hexane, -15 deg C, 5 min, 2) THF, -40 deg C, 1h
2: 60 percent / trifluoroacetic acid / 1,2-dichloro-ethane / 2.5 h / Heating
View Scheme
参考文献
Kakushima, Masatoshi; Frenette, Richard
Journal of Organic Chemistry, 1984 , vol. 49, # 11 p. 2025 - 2027
反应条件
diethylzinc in toluene
T=-12 - 20°C; 18 h;
参考文献
Cramer, Nicolai; Laschat, Sabine; Baro, Angelika; Frey, Wolfgang
Synlett, 2003 , # 14 p. 2175 - 2177
