1: lithium aluminum hydride / dioxane; tetrahydrofuran / Heating 2: 24.82 g / dioxane; H2O / 10 h / 20 °C 3: 75 percent / Ph3P; CCl4 / CH2Cl2 / 24 h / 20 °C 4: 83.1 percent / H2O; ethanol / 5 h / Heating 5: conc. HCl / 4 h / Heating 6: 2.57 g / N,N-diisopropylethylamine / H2O; acetonitrile / 1.25 h View Scheme

1: 24.82 g / dioxane; H2O / 10 h / 20 °C 2: 75 percent / Ph3P; CCl4 / CH2Cl2 / 24 h / 20 °C 3: 83.1 percent / H2O; ethanol / 5 h / Heating 4: conc. HCl / 4 h / Heating 5: 2.57 g / N,N-diisopropylethylamine / H2O; acetonitrile / 1.25 h View Scheme

1: 75 percent / Ph3P; CCl4 / CH2Cl2 / 24 h / 20 °C 2: 83.1 percent / H2O; ethanol / 5 h / Heating 3: conc. HCl / 4 h / Heating 4: 2.57 g / N,N-diisopropylethylamine / H2O; acetonitrile / 1.25 h View Scheme

1: 83.1 percent / H2O; ethanol / 5 h / Heating 2: conc. HCl / 4 h / Heating 3: 2.57 g / N,N-diisopropylethylamine / H2O; acetonitrile / 1.25 h View Scheme

1: conc. HCl / 4 h / Heating 2: 2.57 g / N,N-diisopropylethylamine / H2O; acetonitrile / 1.25 h View Scheme

1: NH3 / ethanol; acetone / 2 h / Ambient temperature 2: DIEA / H2O; acetonitrile / 2 h / Ambient temperature View Scheme

N-ethyl-N,N-diisopropylamine in water; acetonitrile 2 h; Ambient temperature; Yield given;

N-ethyl-N,N-diisopropylamine in water; acetonitrile Acylation; 1.25 h;