N-[(1S)-3-(二甲氧基亚膦酰)-2-氧代-1-(苯基甲基)丙基]-氨基甲酸叔丁酯合成路线 （共 6 条）
反应条件
n-butyllithium in tetrahydrofuran
参考文献
Tossi, Alessandro; Benedetti, Fabio; Norbedo, Stefano; Skrbec, Damiano; Berti, Federico; Romeo, Domenico
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4719 - 4727
反应条件
1: methanephosphonic acid dimethyl ester With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.25 h; Inert atmosphere; 2: N-tert-butoxycarbonyl-L-phenylalanine in tetrahydrofuran; hexane T=-78 - -30°C; 3 h; Inert atmosphere;
参考文献
Benedetti, Fabio; Berti, Federico; Budal, Sara; Campaner, Pietro; Dinon, Francesca; Tossi, Alessandro; Argirova, Radka; Genova, Petia; Atanassov, Vasil; Hinkov, Anton
Journal of Medicinal Chemistry, 2012 , vol. 55, # 8 p. 3900 - 3910
反应条件
1: 100 percent / thionyl chloride / 24 h / 0 - 20 °C 2: nBuLi / tetrahydrofuran / -78 °C View Scheme
参考文献
Rodriguez, Ana Chiva; Ramos, Anna Pico; Hawkes, Geoffrey E.; Berti, Federico; Resmini, Marina
Tetrahedron Asymmetry, 2004 , vol. 15, # 12 p. 1847 - 1855
反应条件
in tetrahydrofuran T=-78°C; Yield given;
参考文献
Benedetti; Miertus; Norbedo; Tossi; Zlatoidzky
Journal of Organic Chemistry, 1997 , vol. 62, # 26 p. 9348 - 9353
反应条件
1: aq. NaOH / dioxane / 0.5 h / 0 °C 2: 100 percent / thionyl chloride / 24 h / 0 - 20 °C 3: nBuLi / tetrahydrofuran / -78 °C View Scheme
参考文献
Nchinda, Aloysius T.; Chibale, Kelly; Redelinghuys, Pierre; Sturrock, Edward D.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 17 p. 4612 - 4615
反应条件
1: aq. NaOH / dioxane / 0.5 h / 0 °C 2: 100 percent / thionyl chloride / 24 h / 0 - 20 °C 3: nBuLi / tetrahydrofuran / -78 °C View Scheme
参考文献
Nchinda, Aloysius T.; Chibale, Kelly; Redelinghuys, Pierre; Sturrock, Edward D.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 17 p. 4612 - 4615
