2-(3-甲氧基苯基)-2-甲基丙腈合成路线 （共 13 条）
反应条件
potassium hydroxide; phenylmethyltriethylammonium bromide in toluene T=80°C; Methylation;
参考文献
Zacheis, David; Dhar, Arindam; Lu, Shennan; Madler, Matora M.; Klucik, Jozef; Brown, Chad W.; Liu, Shengquan; Clement, Francis; Subramanian, Shankar; Mahika Weerasekare; Darrell Berlin; Gold, Michael A.; Houck Jr., John R.; Fountain, Kenneth R.; Benbrook, Doris M.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 21 p. 4434 - 4445
反应条件
potassium hexamethylsilazane in toluene T=100°C; Substitution; 3 h;
参考文献
Caron, Stephane; Vazquez, Enrique; Wojcik, Jill M.
Journal of the American Chemical Society, 2000 , vol. 122, # 4 p. 712 - 713
反应条件
in tetrahydrofuran reaction mixture is stirred at -60°C for 10 min;
参考文献
Kuendig, E. Peter; Desobry, Vincent; Simmons, Dana P.; Wenger, Eric
Journal of the American Chemical Society, 1989 , vol. 111, p. 1804 - 1814
反应条件
NaH in tetrahydrofuran; mineral oil
参考文献
Hoechst Marion Roussel Inc.
Patent: US5962469 A1, 1999 ;
反应条件
iodine in tetrahydrofuran Kinetics; mixing of soln. at -78°C, flask is placed in a bath (-30°C); GLC and high-resolution MS;
参考文献
Kuendig, E. Peter; Desobry, Vincent; Simmons, Dana P.; Wenger, Eric
Journal of the American Chemical Society, 1989 , vol. 111, p. 1804 - 1814
反应条件
Yield given. Multistep reaction;
参考文献
Kuendig, E. Peter; Desobry, Vincent; Simmons, Dana P.; Wenger, Eric
Journal of the American Chemical Society, 1989 , vol. 111, # 5 p. 1804 - 1815
反应条件
potassium hydride 1.) THF, 1 h, 2.) THF, RT, overnight; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Cheng; Uyeno; Polgar; Toll; Lawson; DeGraw; Loew; Camerman
Journal of Medicinal Chemistry, 1986 , vol. 29, # 4 p. 531 - 537
反应条件
(.eta.6-phenylOMe-d3)tricarbonylchromium; (2R)-tricarbonyl(.eta.6-anisole)chromium(0)(+) multistep reaction, double crossover experiments; Product distributionMechanism;
参考文献
Kuendig, E. Peter; Desobry, Vincent; Simmons, Dana P.; Wenger, Eric
Journal of the American Chemical Society, 1989 , vol. 111, # 5 p. 1804 - 1815
反应条件
1: 81 percent / KOH, H2O / methanol / Heating 2: 96 percent / Et3N, diphenyl phosphorazidate / toluene / 3 h / Heating 3: 39 percent / FeCl3 / 1,2-dichloro-ethane 4: 57 percent / BBr3 / CH2Cl2 / Ambient temperature View Scheme
参考文献
Fevig, Thomas L.; Bowen, S. Marc; Janowick, David A.; Jones, Bryan K.; Munson, H. Randall; Ohlweiler, David F.; Thomas, Craig E.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 25 p. 4988 - 4996
反应条件
1: 81 percent / KOH, H2O / methanol / Heating 2: 96 percent / Et3N, diphenyl phosphorazidate / toluene / 3 h / Heating 3: 39 percent / FeCl3 / 1,2-dichloro-ethane View Scheme
参考文献
Fevig, Thomas L.; Bowen, S. Marc; Janowick, David A.; Jones, Bryan K.; Munson, H. Randall; Ohlweiler, David F.; Thomas, Craig E.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 25 p. 4988 - 4996
