2-(3-甲氧基苯基)-2-甲基丙腈合成路线 （共 13 条）
反应条件
1: 69 percent / 50 percent aq. KOH / bis-(2-hydroxy-ethyl) ether / 72 h / 130 - 140 °C 2: 75 percent / LiAlH4 / tetrahydrofuran / 48 h / Heating View Scheme
参考文献
Zacheis, David; Dhar, Arindam; Lu, Shennan; Madler, Matora M.; Klucik, Jozef; Brown, Chad W.; Liu, Shengquan; Clement, Francis; Subramanian, Shankar; Mahika Weerasekare; Darrell Berlin; Gold, Michael A.; Houck Jr., John R.; Fountain, Kenneth R.; Benbrook, Doris M.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 21 p. 4434 - 4445
反应条件
potassium hydroxide; water in methanol Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 25 p. 4988 - 4996
反应条件
1: With borane-THF in tetrahydrofuran
T=0 - 20°C; 1 h;
2: With methanol in tetrahydrofuran
T=0°C;
参考文献
IRM LLC
Patent: WO2008/97428 A2, 2008 ;
Location in patent: Page/Page column 114; 115 ;
WO 2008/097428 A2
