2-(3-甲氧基苯基)-2-甲基丙酸合成路线 （共 10 条）
反应条件
sodium hydroxide; water in ethanol T=70°C; 16 h;
参考文献
WO2004/50619 A1, ;
Page 41 ;
WO 2004/050619 A1
反应条件
potassium hydroxide; water in methanol Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 25 p. 4988 - 4996
反应条件
1: With methanol; lithium hydroxide; water in tetrahydrofuran T=60°C; 7 h; 2: in water Acidic aqueous solution;
参考文献
WO2009/42694 A1, ;
Page/Page column 119 ;
WO 2009/042694 A1
参考文献
Helvetica Chimica Acta, , vol. 54, p. 868 - 897
反应条件
n-butyllithium; lithium diisopropyl amide Yield given. Multistep reaction;
参考文献
Heterocycles, , vol. 20, # 3 p. 451 - 454
反应条件
Yield givenMultistep reaction. Yields of byproduct given;
参考文献
Chemical Communications, , # 2 p. 187 - 188
反应条件
(i) Na, liq. NH3, Et2O, (ii) /BRN= 635994/, Et2O, (iii) aq. KOH, EtOH; Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 11, p. 340 - 342
反应条件
1: 96 percent / Et3N, diphenyl phosphorazidate / toluene / 3 h / Heating 2: 39 percent / FeCl3 / 1,2-dichloro-ethane 3: 57 percent / BBr3 / CH2Cl2 / Ambient temperature View Scheme
参考文献
Fevig, Thomas L.; Bowen, S. Marc; Janowick, David A.; Jones, Bryan K.; Munson, H. Randall; Ohlweiler, David F.; Thomas, Craig E.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 25 p. 4988 - 4996
反应条件
1: 96 percent / Et3N, diphenyl phosphorazidate / toluene / 3 h / Heating 2: 39 percent / FeCl3 / 1,2-dichloro-ethane View Scheme
参考文献
Fevig, Thomas L.; Bowen, S. Marc; Janowick, David A.; Jones, Bryan K.; Munson, H. Randall; Ohlweiler, David F.; Thomas, Craig E.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 25 p. 4988 - 4996
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Reduction; 48 h; Heating;
参考文献
Zacheis, David; Dhar, Arindam; Lu, Shennan; Madler, Matora M.; Klucik, Jozef; Brown, Chad W.; Liu, Shengquan; Clement, Francis; Subramanian, Shankar; Mahika Weerasekare; Darrell Berlin; Gold, Michael A.; Houck Jr., John R.; Fountain, Kenneth R.; Benbrook, Doris M.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 21 p. 4434 - 4445
