1-(3-氟-5-甲氧基苯基)乙酮合成路线 (共 1 条)
反应条件
1: 3-fluoro-5-methoxybenzoic acid With thionyl chloride in toluene 2 h; Reflux; 2: With O,N-dimethyl-hydroxylamine hydrochloride; triethylamine in dichloromethane; toluene T=0 - 20°C; 3: methylmagnesium bromide in diethyl ether T=20°C; 2 h; RefluxInert atmosphere;
参考文献
AiCuris GmbH and Co. KG
Patent: US2011/124618 A1, 2011 ;
Location in patent: Page/Page column 12 ;