1: 5-bromo-2,4-dimethoxy-pyrimidine With magnesium; ethylene dibromide in tetrahydrofuran 3 h; RefluxInert atmosphere; 2: 7,14-dioxa-1-azaspirolt;4.2.5.2gt;pentadec-1-ene 1-oxide in tetrahydrofuran T=-10 - 20°C; Inert atmosphere; 3: With ammonia; copper diacetate in 1,4-dioxane; dichloromethane; water T=20°C; 24 h;

1: 5-bromo-2,4-dimethoxy-pyrimidine With tert.-butyl lithium in tetrahydrofuran; pentane T=-78°C; 0.5 h; Inert atmosphere; 2: 7,14-dioxa-1-azaspirolt;4.2.5.2gt;pentadec-1-ene 1-oxide in tetrahydrofuran; pentane T=-78 - 20°C; Inert atmosphere; 3: With ammonia; copper diacetate in 1,4-dioxane; dichloromethane; water T=20°C; 24 h;