4beta,9alpha,12beta,13alpha,20-五羟基惕各-1,6-二烯-3-酮合成路线 （共 8 条）
反应条件
1: Py 2: NaOMe, MeOH / dioxane View Scheme
参考文献
Bresch,H. et al.
Z. Naturforsch., B: Anorg. Chem., Org. Chem., Biochem., Biophys.,, 1968 , vol. 23, p. 538 - 546
反应条件
1: pyridine / 1 h / 90 °C 2: 80 percent / KOH / methanol / 1 h / 20 °C 3: 75 percent / pyridine / 120 h / 20 °C 4: 65 percent / aq. 4 / methanol View Scheme
参考文献
El-Mekkawy, Sahar; Meselhy, Meselhy Ragab; Abdel-Hafez, Atef Abdel-Monem; Nakamura, Norio; Hattori, Masao; Kawahata, Takuya; Otake, Toru
Chemical and Pharmaceutical Bulletin, 2002 , vol. 50, # 4 p. 523 - 529
参考文献
El-Mekkawy, Sahar; Meselhy, Meselhy Ragab; Abdel-Hafez, Atef Abdel-Monem; Nakamura, Norio; Hattori, Masao; Kawahata, Takuya; Otake, Toru
Chemical and Pharmaceutical Bulletin, 2002 , vol. 50, # 4 p. 523 - 529
反应条件
1: pyridine / 1 h / 90 °C 2: 80 percent / aq. HClO4 View Scheme
参考文献
El-Mekkawy, Sahar; Meselhy, Meselhy Ragab; Abdel-Hafez, Atef Abdel-Monem; Nakamura, Norio; Hattori, Masao; Kawahata, Takuya; Otake, Toru
Chemical and Pharmaceutical Bulletin, 2002 , vol. 50, # 4 p. 523 - 529
反应条件
1: Py 2: (i) NaOMe, MeOH, dioxane, (ii) /BRN= 385737/, Py, (iii) aq. HClO4, MeOH View Scheme
参考文献
Bresch,H. et al.
Z. Naturforsch., B: Anorg. Chem., Org. Chem., Biochem., Biophys.,, 1968 , vol. 23, p. 538 - 546
参考文献
Genentech, Inc.
Patent: US4766075 A1, 1988 ;
反应条件
1: Py
2: (i) NaOMe, MeOH, dioxane, (ii) /BRN= 385737/, Py, (iii) aq. HClO4, MeOH
View Scheme
参考文献
Bresch,H. et al.
Z. Naturforsch., B: Anorg. Chem., Org. Chem., Biochem., Biophys.,, 1968 , vol. 23, p. 538 - 546
反应条件
triethylamine in tetrahydrofuran; dichloromethane
Acetylation; 8 h;
参考文献
Wender, Paul A.; Koehler, Michael F.T.; Wright, Dennis L.; Irie, Kazuhiro
Synthesis, 1999 , # SPEC. ISS. p. 1401 - 1406
