7-溴-1,2,3,4-四氢异喹啉合成路线 （共 16 条）
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine in chloroform T=20°C; 20 h; Cooling with ice;
参考文献
Taisho Pharmaceutical Co., Ltd.; BUSUJIMA, Tsuyoshi; OI, Takahiro; TANAKA, Hiroaki; SHIRASAKI, Yoshihisa; IWAKIRI, Kanako; SATO, Nagaaki; TOKITA, Shigeru
Patent: EP2687507 A1, 2014 ;
Location in patent: Paragraph 0209 ;
反应条件
triethylamine in tetrahydrofuran T=20°C; 1 h;
参考文献
US2010/240671 A1, ;
Page/Page column 58 ;
反应条件
triethylamine in N,N-dimethyl-formamide
参考文献
US5977134 A1, ;
US 5977134 A
反应条件
triethylamine in dichloromethane
T=0°C; 2 h;
参考文献
F. HOFFMANN-LA ROCHE AG; HERMANN, Johannes Cornelius; KUGLSTATTER, Andreas; LUCAS, Matthew C.; PADILLA, Fernando; WANNER, Jutta; ZHANG, Xiaohu
Patent: WO2013/64445 A1, 2013 ;
Location in patent: Page/Page column 128-129 ;
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane
T=0 - 20°C; 15 h;
参考文献
ASTRAZENECA AB; ASTEX THERAPEUTICS LTD
Patent: WO2007/58602 A2, 2007 ;
Location in patent: Page/Page column 77 ;
WO 2007/058602 A2
反应条件
1: triethylamine / dichloromethane / 2 h / 0 °C
2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 15 h / 100 °C / |Inert atmosphere
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参考文献
F. HOFFMANN-LA ROCHE AG; HERMANN, Johannes Cornelius; KUGLSTATTER, Andreas; LUCAS, Matthew C.; PADILLA, Fernando; WANNER, Jutta; ZHANG, Xiaohu
Patent: WO2013/64445 A1, 2013 ;
