2-(二甲基氨基)乙烯基-1-硝基萘合成路线 （共 7 条）
反应条件
in N,N-dimethyl-formamide 1) 140 deg C, 6 h; 2) 25 deg C, 26 h;
参考文献
Riesgo, Elvira C.; Jin, Xiaoqing; Thummel, Randolph P.
Journal of Organic Chemistry, 1996 , vol. 61, # 9 p. 3017 - 3022
反应条件
in toluene T=120°C; 39 h;
参考文献
MERCK SHARP and DOHME CORP.; KUDUK, Scott, D.; CHANG, Ronald, K.; GRESHOCK, Thomas, J.
Patent: WO2012/47702 A1, 2012 ;
Location in patent: Page/Page column 32-33 ;
WO 2012/047702 A1
反应条件
1: With potassium permanganate; potassium carbonate in water; tert-butyl alcohol T=20°C; 17.5 h; 2: With hydrogenchloride in water; tert-butyl alcohol pH=~ 2;
参考文献
MERCK SHARP and DOHME CORP.; KUDUK, Scott, D.; CHANG, Ronald, K.; GRESHOCK, Thomas, J.
Patent: WO2012/47702 A1, 2012 ;
Location in patent: Page/Page column 33 ;
WO 2012/047702 A1
反应条件
sodium periodate in tetrahydrofuran; water T=25°C; 2 h;
参考文献
Riesgo, Elvira C.; Jin, Xiaoqing; Thummel, Randolph P.
Journal of Organic Chemistry, 1996 , vol. 61, # 9 p. 3017 - 3022
反应条件
1.1: potassium carbonate; potassium permanganate / water; tert-butyl alcohol / 17.5 h / 20 °C 1.2: pH ~ 2 2.1: hydrogenchloride / 0 - 90 °C 3.1: hydrogen / 10 palladium on activated charcoal / tetrahydrofuran; methanol / 14 h / 760.05 Torr View Scheme
参考文献
MERCK SHARP and DOHME CORP.; KUDUK, Scott, D.; CHANG, Ronald, K.; GRESHOCK, Thomas, J.
Patent: WO2012/47702 A1, 2012 ;
WO 2012/047702 A1
反应条件
1: 85 percent / sodium periodate / tetrahydrofuran; H2O / 2 h / 25 °C 2: 77 percent / Fe powder, conc. HCl / ethanol; acetic acid; H2O / 1) reflux, 15 min; 2) 25 deg C, 25 min View Scheme
参考文献
Riesgo, Elvira C.; Jin, Xiaoqing; Thummel, Randolph P.
Journal of Organic Chemistry, 1996 , vol. 61, # 9 p. 3017 - 3022
反应条件
hydrogen; palladium on activated charcoal in methanol; dichloromethane
T=20°C;
参考文献
Siu, Jason; Baxendale, Ian R.; Ley, Steven V.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 2 p. 160 - 167
