2-甲基-4(3H)-喹唑酮合成路线 （共 123 条）
反应条件
1: 2-methyl-4-oxo-3,4-dihydroquinazoline With sodium hydride in N,N-dimethyl-formamide; mineral oil T=0°C; 1 h; Inert atmosphere; 2: methyl iodide in N,N-dimethyl-formamide; mineral oil T=25°C; 12 h; Inert atmosphere;
参考文献
Takemura, Noriaki; Kuninobu, Yoichiro; Kanai, Motomu
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 16 p. 2528 - 2532
反应条件
1: dimethylformamide 2: NH2NH2*H2O 3: 1 h / 200 °C View Scheme
参考文献
Allimony; El-Shaaer; Abdel-Hamide; Abdel-Aziz; Abdel-Rahman
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996 , vol. 35, # 10 p. 1026 - 1030
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide 24 h;
参考文献
Bergman, Jan; Brynolf, Anna
Tetrahedron, 1990 , vol. 46, # 4 p. 1295 - 1310
反应条件
T=150 - 180°C; Microwave irradiation;
参考文献
Mrozek-Wilczkiewicz, Anna; Kalinowski, Danuta S.; Musiol, Robert; Finster, Jacek; Szurko, Agnieszka; Serafin, Katarzyna; Knas, Magdalena; Kamalapuram, Sishir K.; Kovacevic, Zaklina; Jampilek, Josef; Ratuszna, Alicja; Rzeszowska-Wolny, Joanna; Richardson, Des R.; Polanski, Jaroslaw
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 7 p. 2664 - 2671
反应条件
1.1: LDA / tetrahydrofuran / 1 h / -78 °C 1.2: 58 percent / tetrahydrofuran / 2 h / -78 °C 2.1: 95 percent / trifluoroacetic acid / methanol / 3 h / Heating View Scheme
参考文献
Philipova; Dobrikov; Krumova; Kaneti
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 4 p. 1057 - 1063
反应条件
N-hydroxy-2,4,6-trimethylbenzensulfonamide; sodium acetate in methanol T=20°C;
参考文献
Ivanov; Tsyrenov; Antonov; Lobanov; Potekhin
Chemistry of Heterocyclic Compounds, 2002 , vol. 38, # 6 p. 710 - 713
反应条件
N-ethyl-N,N-diisopropylamine; trichlorophosphate 2.5 h; Reflux;
参考文献
Shen, Zhen-Lu; He, Xiao-Fei; Hong, Yi-Ming; Hu, Xin-Quan; Mo, Wei-Min; Hu, Bao-Xiang; Sun, Nan
Synthetic Communications, 2011 , vol. 41, # 24 p. 3644 - 3653
反应条件
1: 2-methyl-4-oxo-3,4-dihydroquinazoline With n-butyllithium in tetrahydrofuran T=-78°C; Metallation; 1 h; 2: methyl iodide in tetrahydrofuran T=-78°C; Methylation; 2 h;
参考文献
Smith, Keith; El-Hiti, Gamal A.; Abdel-Megeed, Mohamed F.; Abdo, Mohamed A.
Collection of Czechoslovak Chemical Communications, 1999 , vol. 64, # 3 p. 515 - 526
反应条件
pyridine; N-chloro-succinimide in chloroform 1 h;
参考文献
Ghabrial, Sami S.; Zaki, Mayasoune Y.
Journal of Chemical Research, Miniprint, 1997 , # 7 p. 1560 - 1575
反应条件
phosphorus pentachloride; trichlorophosphate 24 h; Heating;
参考文献
Verhaeghe, Pierre; Rathelot, Pascal; Gellis, Armand; Rault, Sylvain; Vanelle, Patrice
Tetrahedron, 2006 , vol. 62, # 34 p. 8173 - 8176
