2-甲基-4(3H)-喹唑酮合成路线 （共 123 条）
参考文献
Smith; Kent
Journal of Organic Chemistry, 1965 , vol. 30, p. 1312,1313
反应条件
1: 95 percent / nitric acid / H2SO4 2: 87 percent / sodium sulphide / H2O / 2 h / Heating View Scheme
参考文献
Naik; Desai
Journal of the Indian Chemical Society, 1989 , vol. 66, # 7 p. 495 - 497
反应条件
in benzene 4 h; Heating;
参考文献
Allimony; El-Shaaer; Abdel-Hamide; Abdel-Aziz; Abdel-Rahman
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996 , vol. 35, # 10 p. 1026 - 1030
反应条件
1: 60 percent / N,N-dimethylaniline, POCl3 / benzene / 2 h / Heating
2: 10 percent / hydrazine hydrate / benzene / 2 h
3: 96 percent / 2.9 N aq. HCl, NaNO2 / H2O
4: 40 percent / 0.03 h / Heating
View Scheme
参考文献
Hand; Baker
Canadian Journal of Chemistry, 1984 , vol. 62, # 11 p. 2570 - 2577
反应条件
in acetic acid
12 h; Heating;
参考文献
Varma, Rajendra S.; Bahadur, Surendra; Agnihotri, Anil K.
Journal of Chemical & Engineering Data, 1981 , vol. 26, # 1 p. 103 - 104
反应条件
iodine; N-ethyl-N,N-diisopropylamine; triphenylphosphine in dichloromethane
T=20°C; 19 h;
参考文献
Lockman, Jeffrey W.; Klimova, Yevgeniya; Anderson, Mark B.; Willardsen, J. Adam
Synthetic Communications, 2012 , vol. 42, # 12 p. 1715 - 1723
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 20 °C
2: dichloromethane; isopropyl alcohol / 1 h / 20 °C
View Scheme
参考文献
Lockman, Jeffrey W.; Klimova, Yevgeniya; Anderson, Mark B.; Willardsen, J. Adam
Synthetic Communications, 2012 , vol. 42, # 12 p. 1715 - 1723
反应条件
iodine; N-ethyl-N,N-diisopropylamine; triphenylphosphine in dichloromethane
T=20°C; 19 h;
参考文献
Lockman, Jeffrey W.; Klimova, Yevgeniya; Anderson, Mark B.; Willardsen, J. Adam
Synthetic Communications, 2012 , vol. 42, # 12 p. 1715 - 1723
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 20 °C
2: dichloromethane; isopropyl alcohol / 4 h / 20 °C
View Scheme
参考文献
Lockman, Jeffrey W.; Klimova, Yevgeniya; Anderson, Mark B.; Willardsen, J. Adam
Synthetic Communications, 2012 , vol. 42, # 12 p. 1715 - 1723
反应条件
sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide
T=0°C; 48 h; Inert atmosphereReflux;
参考文献
El-Badry, Yaser A.; El-Farargy, Ahmed F.; Eilbracht, Peter
Helvetica Chimica Acta, 2013 , vol. 96, # 9 p. 1782 - 1792
