6-甲氧基-2-苯基四氢萘酮合成路线 （共 24 条）
反应条件
1: (i) aq. NaOH, EtOH, (ii) /BRN= 471223/ 2: AcOH / aq. ethanol 3: aq. H2SO4 4: (i) Zn-Hg, aq. HCl, (ii) HF View Scheme
参考文献
Journal of medicinal chemistry, , vol. 9, # 2 p. 172 - 176
反应条件
1: aq. H2SO4 2: (i) Zn-Hg, aq. HCl, (ii) HF View Scheme
参考文献
Journal of medicinal chemistry, , vol. 9, # 2 p. 172 - 176
反应条件
in diethyl ether; toluene 2 h; Heating;
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 10 p. 1511 - 1516
反应条件
(i) Zn-Hg, aq. HCl, (ii) HF; Multistep reaction;
参考文献
Journal of medicinal chemistry, , vol. 9, # 2 p. 172 - 176
反应条件
2: 45 percent View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 1 p. 107 - 117
反应条件
Yield given. Multistep reaction;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 4 p. 902 - 906
反应条件
1: 1-[2-(4-bromo-phenoxy)-ethyl]-pyrrolidine With n-butyllithium; cerium(III) chloride in tetrahydrofuran; hexane T=-78°C; 4 h; 2: (6-methoxy-2-phenyl-3,4-dihydronaphthalene-1(2H)-one) in tetrahydrofuran; hexane T=20°C; 16 h;
参考文献
LEK PHARMACEUTICALS D.D.; GAZIC SMILOVIC, Ivana; SEECHURN, Carin; COLACOT, Thomas J.
Patent: WO2012/159981 A2, 2012 ;
Location in patent: Page/Page column 20-21 ;
反应条件
1: 1.) Mg / 1.) THF, 2.) THF, room temp, 1 h; reflux, 1 h 2: 72 percent / K2CO3, / acetone / 15 h / Heating View Scheme
参考文献
Bindal, Rajeshwar D.; Durani, S.; Kapil, Randhir S.; Anand, Nitya
Synthesis, 1982 , # 5 p. 405 - 407
反应条件
1: NaBH4 2: AlCl3 View Scheme
参考文献
Bencze; Barsky; Carney; Renzi; De Stevens
Journal of medicinal chemistry, 1967 , vol. 10, # 2 p. 138 - 144
反应条件
magnesium
1.) THF, 2.) THF, room temp, 1 h; reflux, 1 h; Yield given. Multistep reaction;
参考文献
Bindal, Rajeshwar D.; Durani, S.; Kapil, Randhir S.; Anand, Nitya
Synthesis, 1982 , # 5 p. 405 - 407
