反应条件
1: SOCl2 / 3 h / Heating
2: 94.6 percent / Et3N / diethyl ether / 0.5 h / Ambient temperature
3: 78 percent / NaBH4, NaH, 2-propanol / dioxane / 1.) 70 deg C, 2.) reflux, 1 h
4: 97.8 percent / LDA / tetrahydrofuran / 1.) 1 h, -78 deg C, 2.) 2 h, ice bath, 3.) 0.5 h, r.t.
5: 100 percent / NaIO4 / H2O; methanol / 20 h / Ambient temperature
6: LDA / tetrahydrofuran / 1.) -78 deg C, 30 min, 2.) 30 min, ice bath
7: Al-Hg / tetrahydrofuran; H2O / 6 h / Heating
View Scheme
参考文献
Ohtsuka, Yasuo; Oishi, Takeshi
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 2 p. 454 - 465
