反应条件
1: 88 percent / Na / 6 h / Heating
2: 72 percent / SOCl2 / 1 h / 80 °C
3: 66 percent / SnCl4 / CH2Cl2 / 3 h / 0 - 20 °C
4: 84 percent / KOH, 85percent hydrazine hydrate / various solvent(s) / 4 h / Heating
5: 1.) 10percent aq. Na2CO3, 2.) H2 / 2.) 10percent Pd/C / 1.) EtOH, reflux, 18 h, 2.) EtOH, 40 psi, 18 h
6: 87 percent / NaI, chlorotrimethylsilane / acetonitrile / 18 h / Heating
7: 73 percent / hexamethylphosphoric acid triamide / 0.5 h / 0 °C
8: 80 percent / diethyl ether / 12 h / 0 - 5 °C
9: 1.) (n-Bu)3SnH, azobisbutyronitrile, 2.) iodine monochloride / 1.) toluene, reflux, 6 h, 2.) CCl4
10: 91 percent / 1 N aq. NaOH / ethanol / 1 h / Heating
View Scheme
参考文献
Goodman, Mark M.; Callahan, A. P.; Knapp, F. F.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 807 - 815
