N,N-二甲基环丙烷羧酰胺合成路线 （共 5 条）
反应条件
1: cyclopropionyl chloride With thionyl chloride; N,N-dimethyl-formamide T=25 - 30°C; 3.5 h; Heating / reflux; 2: dimethylammonium chloride With sodium hydroxide in water T=0 - 25°C; 2.5 h;
参考文献
EGIS GYOGYSZERGYAR Nyilvanosan Mkoed Reszvenytarsasag
Patent: WO2009/68923 A2, 2009 ;
Location in patent: Page/Page column 7-8 ;
反应条件
in water T=0°C; 1 h;
参考文献
Buswell, Marina; Fleming, Ian; Ghosh, Usha; Mack, Stephen; Russell, Matthew; Clark, Barry P.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 20 p. 3006 - 3017
反应条件
(i) MeCN, (ii) aq. NaOH; Multistep reaction;
参考文献
Hobbs,C.F.; Weingarten,H.
Journal of the American Chemical Society, 1969 , vol. 91, p. 780 - 781
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Hobbs,C.F.; Weingarten,H.
Journal of Organic Chemistry, 1974 , vol. 39, p. 918 - 921
反应条件
1: 1-(chloromethyl)-2-fluorobenzene With iodine; magnesium in diethyl ether 2 h; Heating / reflux; 2: cyclopropanecarboxylic acid dimethylamide in tetrahydrofuran; diethyl ether 0.5 h; Product distribution / selectivity;
参考文献
EGIS GYOGYSZERGYAR Nyilvanosan Mkoed Reszvenytarsasag
Patent: WO2009/68923 A2, 2009 ;
Location in patent: Page/Page column 9-10 ;
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Blomquist,A.T.; Connolly,D.J.
Journal of Organic Chemistry, 1961 , vol. 26, p. 2573 - 2575
