1: para-bromobenzonitrile With sodium methylate in methanol T=20°C; 5.5 h; 2: 2-aminoacetaldehyde dimethyl acetal With acetic acid in methanol T=50°C; 1 h; 3: With hydrogenchloride in methanol T=65°C; 18 h;
potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in dimethyl sulfoxide T=80°C;
参考文献
UNIVERSITY OF ROCHESTER; BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA; GELBARD, Harris A.; DEWHURST, Stephen; GENDELMAN, Howard E.
Patent: WO2014/85795 A1, 2014 ;
Location in patent: Paragraph 0361 ;
