3-(二氟甲基)-1-甲基-1H-吡唑-4-羧酸合成路线 （共 18 条）
反应条件
1: With sodium hydroxide; dihydrogen peroxide in water T=40 - 45°C; 1.5 h; 2: With hydrogenchloride in water pH=2.5; Product distribution / selectivity;
参考文献
EP2008996 A1, ;
Page/Page column 9; 10 ;
反应条件
hydrogenchloride in water; isopropyl alcohol T=65 - 85°C; Product distribution / selectivity;
参考文献
WO2011/113788 A1, ;
Page/Page column 11 ;
反应条件
1: 3-piperidin-1-yl-acrylic acid methyl ester; difluoroacetic acid fluoride With potassium fluoride in toluene T=-30 - 20°C; 4 h; 2: methylhydrazine in toluene T=-50 - 20°C; 3 h; Product distribution / selectivity;
参考文献
US2011/40096 A1, ;
Page/Page column 11 ;
反应条件
1: N,N-dimethylamino-1,1,2,2-tetrafluoroethane With boron trifluoride diethyl etherate in 1,4-dioxane; diethyl ether T=0 - 5°C; Inert atmosphere; 2: 3-methoxyacrylic acid methyl ester With pyridine in 1,4-dioxane; diethyl ether T=0 - 5°C; 3: methylhydrazine Product distribution / selectivity;
参考文献
US2010/184994 A1, ;
Page/Page column 9 ;
反应条件
triethylamine tris(hydrogen fluoride) T=250°C; 0.0833333 h; Neat (no solvent)Microwave irradiation;
参考文献
Tetrahedron Letters, , vol. 50, # 26 p. 3665 - 3668
反应条件
1.1: sodium hydroxide / toluene; ethanol; water / 3 h / -3 - 20 °C 2.1: sodium hydroxide / water / 2 h / 60 °C 2.2: 20 °C / pH 1 View Scheme
反应条件
thionyl chloride in chlorobenzene T=110°C; 3 h;
参考文献
WO2007/31323 A1, ;
Page/Page column 27 ;
反应条件
2-(CH2NMe2)-Ph-B(OH)2 in xylene T=143°C; 10 h; Molecular sievesInert atmosphere; Product distribution / selectivity;
参考文献
SYNGENTA LIMITED; SYNGENTA PARTICIPATIONS AG
Patent: WO2009/138375 A1, 2009 ;
Location in patent: Page/Page column 32-33 ;
