2-氨基-2-甲基-丙酰胺盐酸盐合成路线 （共 5 条）
参考文献
Gulewitsch; Wasmus
Chemische Berichte, 1906 , vol. 39, p. 1192
反应条件
MP-carbonate in methanol 4 h; Polystyrene;
参考文献
GLAXO GROUP LIMITED
Patent: WO2008/17691 A1, 2008 ;
Location in patent: Page/Page column 26 ;
WO 2008/017691 A1
反应条件
1: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane
T=20°C; 2 h;
2: With ammonia in dichloromethane
T=20°C; 0.166667 h;
3: With hydrogenchloride in diethyl ether; dichloromethane
T=20°C; 15 h;
参考文献
National Health Research Institutes
Patent: US2010/113546 A1, 2010 ;
Location in patent: Page/Page column 16 ;
反应条件
hydrogenchloride in 1,4-dioxane
T=20°C; 1 h;
参考文献
Novartis AG
Patent: US6353017 B1, 2002 ;
Location in patent: Page column 27 ;
US 6353017 B1
反应条件
hydrogenchloride; 2-hydroxyethanethiol in tetrahydrofuran
T=-78°C;
参考文献
Lee, Young Bok; Goo, Yang Mo; Lee, Youn Young; Lee, Jae Keun
Tetrahedron Letters, 1990 , vol. 31, # 8 p. 1169 - 1170
